LEONARD STERN, MD: The body is remarkably resilient, and you could be largely asymptomatic with loss of as much as 85% to 90% of kidney function, but when you reach about 10% of kidney function, you begin to get symptoms. Those symptoms may be related to appetite reduction, nausea, fatigue, and a variety of progressive symptoms that produce a syndrome which we call renal failure.
In years past, we waited until patients were symptomatic, and then we initiated dialysis. Our approach today is a bit different. When patients reach that 10% approximate level, we try to get them to start dialysis sooner, when they're asymptomatic, because we think their survival is improved.
LISA CLARK: Jai, there are two major types of dialysis, hemodialysis, which is through the bloodstream, and then peritoneal dialysis. Will you just highlight the chief differences for our audience?
JAI RADHAKRISHNAN, MD: The basic principle of dialysis is that you need a membrane through which the exchange of fluid and toxins can occur. In hemo-, or blood, dialysis, there is a machine with an external membrane inside the machine that does this exchange. In peritoneal dialysis, we use the body's own membrane, and we use what's called the peritoneal membrane -- that is the lining of all the organs inside the abdominal cavity through which the exchange occurs.
LISA CLARK: If you wouldn't mind describing the basics of peritoneal dialysis for us, Len? I know this is complicated, but try to help us understand.